With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.80194-69-0, name is 5-(Trifluoromethyl)picolinic acid, molecular formula is C7H4F3NO2, molecular weight is 191.1074, as common compound, the synthetic route is as follows.Product Details of 80194-69-0
A mixture containing CoCl26H2O (12.40 mg, 0.05 mmol), Htpc (9.50 mg, 0.05 mmol),and water (6 mL) was sealed in a 15-mL Teflon-lined stainless steel vessel and heatedat 413 K for 3 days and then cooled to room temperature at a rate of 10 Kh1. Afterfiltration, red block crystals were collected and washed with distilled water severaltimes, then dried at room temperature. Yield: 4.96mg (40%, based on CoCl26H2O).Anal. Calcd (%) for C14H10CoF6N2O6 (molecular weight 475.17 gmol1): C, 35.39; H, 2.12; N, 5.90. Found (%): C, 35.54; H, 2.21; N, 5.98. IR (KBr, cm1): 3347 w, 1663 m,1510 m, 1410 m, 1148w, 936 w, 820 w, 640 w, 473 w.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,80194-69-0, 5-(Trifluoromethyl)picolinic acid, and friends who are interested can also refer to it.
Reference:
Article; Li, Bing; Wang, Jiakai; Song, Huan; Wu, Huanping; Chen, Xiaoyan; Ma, Xiaoxia; Journal of Coordination Chemistry; vol. 72; 15; (2019); p. 2562 – 2573;,
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