Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines was written by Monnard, Fabien W.;Nogueira, Elisa S.;Heinisch, Tillmann;Schirmer, Tilman;Ward, Thomas R.. And the article was included in Chemical Science in 2013.COA of Formula: C6H6BrNO This article mentions the following:
In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asym. transfer hydrogenation of imines. Critical cofactor-protein interactions revealed by the x-ray structure of [(η5-Cp*)Ir(pico 4)Cl] 9 ⊂ WT hCA II were genetically optimized to improve the catalytic performance of the artificial metalloenzyme (68% ee, kcat/Km 6.11 × 10-3 min-1 mM-1). In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0COA of Formula: C6H6BrNO).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C6H6BrNO