With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52313-50-5, name is Picolinimidamide, molecular formula is C6H7N3, molecular weight is 121.14, as common compound, the synthetic route is as follows.COA of Formula: C6H7N3
Intermediate 108: ethyl 6-hvdroxy-2-(2-pyridinyl)-4-pyrimidinecarboxylateDiethyl 2-oxobutanedioate (4.31 mL, 26.6 mmol)(TCI Europe) was added to a suspension of 2- pyridinecarboximidamide (4.19 g, 26.6 mmol)(Alfa Aesar) in Ethanol (130 mL) at r.t. under nitrogen. Triethylamine (7.41 mL, 53.1 mmol) was added dropwise and the reaction mixture heated to 80 C and stirred for 24 h in total. The reaction was allowed to cool to r.t. and concentrated in vacuo to a black oil. The crude product was purified by column chromatography using a 0 to 100% solution of 20% MeOH in DCM/DCM to give the title product as a brown oil (2.91 g, 45% yield) which was used in the subsequent reaction without further purification.LCMS (Method A): Rt = 0.69 min, MH+ = 246.1
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52313-50-5, Picolinimidamide, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
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