Selective C-H Bond Fluorination of Phenols with a Removable Directing Group: Late-Stage Fluorination of 2-Phenoxyl Nicotinate Derivatives was written by Lou, Shao-Jie;Chen, Qi;Wang, Yi-Feng;Xu, Dan-Qian;Du, Xiao-Hua;He, Jiang-Qi;Mao, Yang-Jie;Xu, Zhen-Yuan. And the article was included in ACS Catalysis in 2015.SDS of cas: 4783-68-0 This article mentions the following:
A facile and site-selective C-H bond fluorination of phenols using removable 2-pyridyloxy group as an auxiliary was developed. E.g., in presence of Pd(dba)2 and N-fluorobenzenesulfonimide, fluorination of 2-phenoxypyridine gave 81% I. Alternatively, late-stage C-H bond fluorination of bioactive 2-phenoxyl nicotinate derivatives and diflufenican were also feasible under the present strategy. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 4783-68-0