Room temperature Ru(III)-catalyzed ortho-hydroxymethylation of arenes was written by Zhang, Yong;Yang, Zhongzhen;Yu, Xinling;Cheng, Xu;Li, Weijian;Guo, Lingmei;Hai, Li;Guo, Li;Wu, Yong. And the article was included in Youji Huaxue in 2018.Computed Properties of C12H11N This article mentions the following:
Direct synthesis of the hydroxymethylated arene derivatives via ruthenium(III)-catalyzed nitrogen atom directed C-H activation is described. The reaction proceeds smoothly at room temperature and generates the corresponding products in moderate to excellent yields. Meanwhile, it has a broad substrate scope and opens up an attractive avenue for the application of direct hydroxymethylation in the synthesis of biol. active compounds In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Computed Properties of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C12H11N