Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides was written by Morisawa, Yasuhiro;Kataoka, Mitsuru;Sakamoto, Toshiaki;Nagahori, Hitoshi;Kitano, Noritoshi;Kusano, Kenichi. And the article was included in Journal of Medicinal Chemistry in 1978.COA of Formula: C7H10N2 This article mentions the following:
Twelve methyl-2-nitro- and 9 methyl-3-nitropyridinecarboxamides were prepared and tested in vivo for anticoccidial activity against Eimeria tenella. Almost all the compounds were active, with optimal activity shown by 5-methyl- (I) [65169-65-5] and 6-methyl-2-nitroisonicotinamide (II) [60780-18-9], which were as potent as 2-nitroisonicotinamide. At least 1 H atom adjacent to the NO2 group is important for anticoccidial activity and a Me group adjacent to the CONH2 function sometimes enhances activity. In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0COA of Formula: C7H10N2).
3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C7H10N2