Synthesis and antimycobacterial activity of 4-(5-substituted-1,3,4-oxadiazol-2-yl)pyridines was written by Navarrete-Vazquez, Gabriel;Molina-Salinas, Gloria Maria;Duarte-Fajardo, Zetel Vahi;Vargas-Villarreal, Javier;Estrada-Soto, Samuel;Gonzalez-Salazar, Francisco;Hernandez-Nunez, Emanuel;Said-Fernandez, Salvador. And the article was included in Bioorganic & Medicinal Chemistry in 2007.Electric Literature of C12H8N4O This article mentions the following:
Twelve 4-(5-Substituted-1,3,4-oxadiazol-2-yl)pyridine derivatives were synthesized and evaluated for their in vitro antimycobacterial activity. Some compounds showed an interesting activity against Mycobacterium tuberculosis H37Rv and five clin. isolates (drug-sensitive and -resistant strains). 4-(5-Pentadecyl-1,3,4-oxadiazol-2-yl)pyridine was 10 times more active than isoniazid, 20 times more active than streptomycin, and 28 times more potent than ethambutol against drug-resistant strain CIBIN 112. 4-(5-Heptadecyl-1,3,4-oxadiazol-2-yl)pyridine showed the same behavior as 4-(5-pentadecyl-1,3,4-oxadiazol-2-yl)pyridine. Both of the above structures bear a high lipophilic chain bonded to the 5-position of the oxadiazole moiety. This fact implies that there exists a contribution of lipophilicity, which could facilitate the entrance of these mols. through lipid-enriched bacterial cell membrane. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Electric Literature of C12H8N4O).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of â?8.7 à 10â? cm3·molâ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâ? in the liquid phase and 140.4 kJ·molâ? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C12H8N4O