Reference of 942947-94-6 ,Some common heterocyclic compound, 942947-94-6, molecular formula is C5H4BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Production Example 23-1 tert-Butyl N-(5-bromo-4-chloropyridin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate To a solution of 5-bromo-4-chloropyridin-2-amine (3.0 g, 14 mmol), di-tert-butyl dicarbonate (9.5 g, 43 mmol), and triethylamine (6.1 mL, 43 mmol) in tetrahydrofuran (100 mL), 4-dimethylaminopyridine (0.18 g, 1.5 mmol) was added, and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and then the residue was separated and purified by silica gel column chromatography (ethyl acetate:heptane) to obtain the title compound (3.2 g, 55% yield). 1H-NMR Spectrum (400 MHz, CDCl3) delta (ppm): 1.48 (s, 18H), 7.47 (s, 1H), 8.58 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 942947-94-6, 5-Bromo-4-chloropyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai R&D Management Co., Lt.d; Tanaka, Keigo; Fukuyama, Takashi; Murai, Norio; Itano, Wataru; Hirota, Shinsuke; Iida, Daisuke; Azuma, Hiroshi; (32 pag.)US2016/168176; (2016); A1;,
Pyridine – Wikipedia,
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