According to the analysis of related databases, 139585-70-9, the application of this compound in the production field has become more and more popular.
Synthetic Route of 139585-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-70-9, name is 6-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
Example 10: [6-cyano-3-(4-methanesulfonylbenzyl)-2-methylindolizin-1- yl]acetic acid30Preparation 10a: 3-(5-cyanopyridin-2-yl)propionic acid ethyl ester A solution of 3-ethoxy-3-oxopropylzinc bromide in tetrahydrofuran (0.5 M, 60 ml_) was added dropwise over a period of 45 minutes to a mixture of 6- bromonicotinonitrile (5.0 g), tetrakis(triphenylphosphine)palladium(0), (0.69 g) and tetrahydrofuran (20 ml_) at room temperature and the resulting mixture was stirred at room temperature for 6 hours. The mixture was diluted with water (150 ml_), basified by the addition of saturated aqueous sodium hydrogen carbonate solution and extracted with methyl te/t-butyl ether. The combined extracts were dried over magnesium sulfate and the solvent removed under reduced pressure. Purification of the residue by column chromatography on silica gel, eluting with a mixture of pentane, dichloromethane and ethyl acetate (2:1 :0, 0:1 :0 and 0:5:1 by volume) gave title compound as a pale yellow oil, 4.1 g.1H NMR (CDCI3): delta 1.25 (m, 3H), 2.85 (t, J = 7.2 Hz, 2H), 3.2 (t, J = 7.2 Hz, 2H), 4.15 (m, 2H), 7.35 (d, J = 8.0 Hz, 1 H), 7.85 (m, 1 H), 8.80 (s, 1 H). MS: ESI (+ve) (Method B): 205 (M+H)+, Retention time 2.7 min.
According to the analysis of related databases, 139585-70-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARGENTA DISCOVERY LIMITED; WO2008/74966; (2008); A1;,
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