Electric Literature of 152460-09-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 152460-09-8 as follows.
N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine (35 g, 0.114 mol) and stannous chloride dihydrate (128.5 g, 0.569 mol) were dissolved in a solvent mixture of ethyl acetate and ethanol (250 ml, 10/1, v/v), and the reaction solution was refluxed for 4 hours. The solution was cooled to room temperature, washed with 10% aqueous sodium hydroxide solution, and concentrated to give N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine (35 g). Rf=0.45 (Methylene chloride_Methanol=9:1). 1H-NMR(DMSO-d6)=2.04(s, 3H), 6.30-6.34(m, 1H), 6.76-6.77(m, 1H), 6.84-6.87 (d, 1H), 7.34-7.35(m, 1H), 7.50-7.56(m, 1H), 8.38-8.47(m, 1H), 8.53-8.57(m, 2H), 8.66-8.70(m, 1H), 9.23-9.24(d, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,152460-09-8, its application will become more common.
Reference:
Patent; IL YANG PHARM. CO., LTD.; US2004/248918; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem