Chemistry is an experimental science, Formula: C8H11NO3S, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 15471-17-7, Name is 3-(Pyridin-1-ium-1-yl)propane-1-sulfonate, molecular formula is C8H11NO3S, belongs to pyridine-derivatives compound. In a document, author is Filipovic, Nenad R..
Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study
The first complexes of 2-pyridylthiocyanate (L) and silver nitrate (1) and perchlorate (2) were prepared and characterized by a single crystal X-ray analysis. The common structural motif of both 1 and 2 is coordination of two L molecules via pyridine nitrogen atom to Ag(I). In order to properly describe the nature of coordinative bonds in 1 and 2, as well as crystal packings in respective structures, a Quantum Theory of Atoms in Molecule topological analysis was performed. Coordinated nitrate ion provides more electron density to Ag(I) in comparison to perchlorate ion. Additional electron density in the case of 2 was provided by the coordination of third L molecule via thiocyanate nitrogen atom resulting in a 1D polymeric structure. Detailed computational analysis of intermolecular interactions, as well analysis of interactions between pyridine ring and -SCN group was performed. Antiproliferative activity of monomeric compound I was found to be better than of cisplatin on three out of four studied human cancer cell lines. Docking studies indicate intercalation as a major binding mode of 1 to DNA, while human serum albumin was revealed as possible carrier for distribution of 1 in the blood stream. (C) 2019 Elsevier Ltd. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 15471-17-7, in my other articles. Formula: C8H11NO3S.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem