A facile synthesis of 2-chloro-1,8-naphthyridine-3-carbaldehyde; their transformation into different functionalities and antimicrobial activity was written by Kumar, M. Ranadheer;Laxminarayana, E.;Ramesh, D.;Sreenivasulu, B.;Chary, M. Thirumala. And the article was included in International Journal of Chemical Sciences in 2010.COA of Formula: C7H9N3O This article mentions the following:
2-Chloro-1,8-naphthyridine-3-carbaldehydes (I) were synthesized through Vilsmeier-Haack cyclization treating N-(pyridin-2-yl)acetamides with POCl3 in DMF. The cyclization was facilitated by N-(pyridin-2-yl)acetamides bearing electron-donating groups at meta position. Condensation of I with N2H4.H2O and NaOAc in MeOH gave the corresponding hydrazones. Treatment of I with NaN3 in EtOH led to cyclization to afford tetrazolo[1,5-a](1,8)naphthyridine-4-carbaldehydes via unstable 2-azido compounds Reaction of I with Na2S in DMF yielded 2-mercapto-1,8-naphthyridine-3-carbaldehydes. The synthesized new compounds were screened for antimicrobial activity. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3COA of Formula: C7H9N3O).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of â?8.7 à 10â? cm3·molâ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâ? in the liquid phase and 140.4 kJ·molâ? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C7H9N3O