O-Substituted pyridine N-oxide derivatives. I. N-(Trimethylammoniumethoxy)pyridinium compounds, a new type of choline derivatives was written by Augustinsson, Klas Bertil;Hasselquist, Hans. And the article was included in Acta chem. Scand. in 1961.Name: 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Treating the N-oxides of pyridine and the picolines without solvent at approx. 120° and N-oxides of 4-picoline and of the lutidines in acetonitrile at reflux temperature with bromocholine gave the title compounds The reaction of 2,6-lutidine N-oxide was carried out at 100° in the presence of water under pressure. The N-oxide of 2,5-lutidine, prepared by H2O2 in AcOH, b. 149°; picrate m. 128-9° (EtOH). The 3,5-isomer b23 166-8°, hygroscopic solid (C6H6). Also were prepared: 75% N-(2-trimethylammoniumethoxy)pyridinium dibromide, m. 198°; 51% N-(2-trimethylammoniumethoxy)-2-picolinium dibromide, m. 196°; 14% 3-isomer, m. 175°; 50% 4-isomer, m. 190°; 67% N-(2-trimethylammoniumethoxy)- 2,4-lutidinium dibromide, m. 195-5.5°; 49% 2,5-isomer, m. 191°; 9.5% 2,6-isomer, m. 175-5.5°; 100% 3,5-isomer, m. 196.5-7°. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Name: 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 3,5-Dimethylpyridine 1-oxide