Rhodium(III)-Catalyzed Activation of Csp3-H Bonds and Subsequent Intermolecular Amidation at Room Temperature was written by Huang, Xiaolei;Wang, Yan;Lan, Jingbo;You, Jingsong. And the article was included in Angewandte Chemie, International Edition in 2015.Formula: C9H14N2 This article mentions the following:
Disclosed herein is a RhIII-catalyzed chelation-assisted activation of unreactive Csp3-H bonds, thus enabling an intermol. amidation of 2-alkylpyridines I (R1 = H, 4-Me, 5-F, 5-Me, 5-MeO; R2 = R3 = Me, Ph; R2 = n-Bu, MeO2C, EtOCH2, etc., R3 = Me) with amides and sulfonamides R3NH2 (R3 = F3CCO, MeSO2, 4-O2NC6H4SO2, etc.) to provide a practical and step-economic route to 2-(pyridin-2-yl)ethanamine derivatives II. Substrates with other N-donor groups (3-isoquinolinyl, cyclohexylideneaminooxy, 5,6-dihydro-1,4,2-dioxazin-3-yl, etc.) are also compatible with the amidation. This protocol proceeds at room temperature, has a relatively broad functional group tolerance and high selectivity, and demonstrates the potential of rhodium(III) in the promotive functionalization of unreactive Csp3-H bonds. A rhodacycle having a SbF6– counterion was identified as a plausible intermediate. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Formula: C9H14N2).
2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C9H14N2