Visible-Light-Promoted Copper-Catalyzed Regioselective Benzylation of Pyridine N-Oxides versus Thermal Acylation Reaction with Toluene Derivatives was written by Kianmehr, Ebrahim;Gholamhosseyni, Maral. And the article was included in European Journal of Organic Chemistry in 2018.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Copper-catalyzed visible light mediated direct C-H bond benzylation of pyridine N-oxides with toluene derivatives was accomplished by recent developments in photochem. carbon-carbon bond formation through a photo-induced bond-dissociation strategy. This visible light driven protocol has been successfully applied to a broad scope of pyridine N-oxides and toluene derivatives Furthermore, preliminary research indicates that the acylation reaction can be carried out under thermal reaction conditions. This protocol provides easy access to 2-benzyl and 2-acyl pyridine N-oxide derivatives in the presence of a copper catalyst. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide