Monodisperse CuPd alloy nanoparticles as efficient and reusable catalyst for the C (sp2)-H bond activation was written by Huang, Fei;Wang, Feifan;Hu, Qiyan;Tang, Lin;Xu, Dongping;Fang, Yang;Zhang, Wu. And the article was included in Applied Organometallic Chemistry in 2021.Application In Synthesis of 2-(m-Tolyl)pyridine This article mentions the following:
Metal-catalyzed selective activation of C-H bonds is very important for the construction of a variety of biol. active mols. Supported alloy nanoparticles are of great interest in various catalytic applications due to the synergistic effects between different metals. Here, well-dispersed CuPd alloy nanoparticles supported on reduced graphene oxide (rGO) were synthesized and found to be highly efficient and recyclable catalyst for the chelation-assisted C(sp2)-H bond activation. Aromatic ketones or esters were synthesized via the cross-dehydrogenative coupling (CDC) reaction between 2-arylpyridines and alcs. or acids [e.g., 2-phenylpyridine + benzyl alc. → I (94%)]. Moreover, the catalyst was recovered and used for five times without significantly losing activity. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application In Synthesis of 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application In Synthesis of 2-(m-Tolyl)pyridine