Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction was written by Lipp, Benjamin;Kammer, Lisa Marie;Kuecuekdisli, Murat;Luque, Adriana;Kuehlborn, Jonas;Pusch, Stefan;Matuleviciute, Gita;Schollmeyer, Dieter;Sackus, Algirdas;Opatz, Till. And the article was included in Chemistry – A European Journal in 2019.Safety of 4-Methylpicolinonitrile This article mentions the following:
Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomols. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Safety of 4-Methylpicolinonitrile).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 4-Methylpicolinonitrile