C-H Cyanation of 6-Ring N-Containing Heteroaromatics was written by Elbert, Bryony L.;Farley, Alistair J. M.;Gorman, Timothy W.;Johnson, Tarn C.;Genicot, Christophe;Lallemand, Benedicte;Pasau, Patrick;Flasz, Jakub;Castro, Jose L.;MacCoss, Malcolm;Paton, Robert S.;Schofield, Christopher J.;Smith, Martin D.;Willis, Michael C.;Dixon, Darren J.. And the article was included in Chemistry – A European Journal in 2017.COA of Formula: C8H6N2O2 This article mentions the following:
Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chem. and the biomedical sciences. Herein, we report an approach to heteroaromatic C-H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures. In the experiment, the researchers used many compounds, for example, Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4COA of Formula: C8H6N2O2).
Methyl 6-Cyanopyridine-3-carboxylate (cas: 89809-65-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C8H6N2O2