Unprecedented orientation in the nitration of certain 3-pyridinols was written by De Selms, Roy C.. And the article was included in Journal of Organic Chemistry in 1968.SDS of cas: 15128-90-2 This article mentions the following:
2-(X-Substituted)-4-nitro-3-pyridinols (I) and 2-(X-substituted)-6-nitro-3-pyridinols (II) are prepared The nitration of 3-pyridinol gives 3-hydroxy-2-nitropyridine containing 5-hydroxy-2-nitropyridine when ether is used as the final extraction solvent. 2-Methyl- and chloro-3-pyridinols are nitrated to give I (X = Me and Cl) and II (X = Me and Cl) in a 4:1 I-II ratio. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2SDS of cas: 15128-90-2).
3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 15128-90-2