Dual resonance functionality in pyridine 1-oxides. A double multinuclear NMR approach was written by Sawada, Masami;Takai, Yoshio;Yamano, Satoshi;Misumi, Soichi;Hanafusa, Terukiyo;Tsuno, Yuho. And the article was included in Journal of Organic Chemistry in 1988.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Substituent effects on the nitrogen-15 NMR chem. shifts of 3- and 4-substituted pyridine 1-oxides in DMSO at natural abundance are reported for 26 derivatives A bilinear relationship is found between the 15N SCS (substituent chem. shift) of pyridine 1-oxides and the 13C SCS of the corresponding mono-substituted benzenes. Both the present 15N SCS data and the reported 17O SCS data of pyridine 1-oxides are analyzed by using the Ukawa-Tsuno’s LSFE and the Taft’s DSP LFER. The historically-accepted dual functionality of pyridine 1-oxides can be successfully expressed in terms of electron-donating and electron-accepting pi-electronic contributions by means of the LSFE treatment. The resulting internal consistency of the constant pi-electronic effect’s ratio, ρπ+/ρπ– = 1.4, on the detecting nitrogen and oxygen is taken as evidence for justification of the dual functionality of the pyridinee 1-oxides and then, for rationalization of the LSFE treatment. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application In Synthesis of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide