Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles was written by Haugwitz, R. D.;Maurer, B. V.;Jacobs, G. A.;Narayanan, V. L.;Cruthers, L.;Szanto, J.. And the article was included in Journal of Medicinal Chemistry in 1979.Recommanded Product: 1620-76-4 This article mentions the following:
The title compounds I (R1 = H, Cl, O, Me, MeO, NCS; R2 = H, Cl, or Me; R3 = H or NCS) were prepared and tested for anthelmintic activity in mice exptl. infected with Nematospiroides dubius (nematode) and Hymenolepis nana (Tapeworm), and in sheep naturally infected with gastrointestinal nematodes. The compounds were used at 0.2% in the mouse diet and at 50 mg/kg, orally in sheep. None of the compounds showed activity against N. dubius, 6 showed 100% activity against H. nana and 1-isothiocyanato-2-(2-pyridinyl)-1H-benzimidazole [71134-39-9] showed nematocidal activity in sheep. Maximum activity required attachment of SCN group at the 5(6) position. Structural activity relations are discussed. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 1620-76-4