New Strategic Reactions for Organic Synthesis: Catalytic Asymmetric C-H Activation α to Nitrogen as a Surrogate for the Mannich Reaction was written by Davies, Huw M. L.;Venkataramani, Chandrasekar;Hansen, Tore;Hopper, Darrin W.. And the article was included in Journal of the American Chemical Society in 2003.Electric Literature of C10H17NO2 This article mentions the following:
The asym. C-H activation reactions of Me aryldiazoacetates are readily induced by the rhodium prolinate catalyst Rh2(S-DOSP)4 [DOSP = (4-dodecylphenylsulfonyl)prolinato] or the bridged prolinate catalysts, and the donor/acceptor-substituted carbenoids generated displayed remarkable chemoselectivity, which allows for highly regioselective, diastereoselective, and enantioselective reactions to be achieved. For example, the C-H activation/rhodium carbenoid induced insertion reactions of N-Boc-protected cyclic amines I (n = 1, 3, 4) with Me phenyldiazoacetate gave the corresponding esters II with excellent diastereoselectivity and enantioselectivity. Furthermore, the reactions can display high levels of double stereodifferentiation and kinetic resolution, as shown in the studies of the double C-H activation/carbenoid insertion reactions. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Electric Literature of C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Electric Literature of C10H17NO2