Rhodium(III)-catalyzed aromatic C-H cyanation with dimethylmalononitrile as a cyanating agent was written by Li, He;Zhang, Sheng;Yu, Xiaoqiang;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Computed Properties of C12H11N This article mentions the following:
A rhodium-catalyzed aromatic C-H bond direct cyanation with safe, bench-stable, and com. available dimethylmalononitrile as the cyanating agent has been successfully developed by using copper oxide as a promotor. Pyridine, quinoline, pyrimidine and pyrazole were used as the directing group in this type of C-H bond direct cyanation reaction. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Computed Properties of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C12H11N