A novel class of potent NF-κB signaling inhibitors was written by Leban, Johann;Baierl, Marcel;Mies, Jan;Trentinaglia, Viola;Rath, Sandra;Kronthaler, Kerstin;Wolf, Kristina;Gotschlich, Astrid;Seifert, Markus H. J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Synthetic Route of C11H20N2O2S This article mentions the following:
A novel class of NF-κB pathway signaling inhibitors was discovered by virtual screening, medicinal chem., and QSAR anal. An initial set of compounds inhibited NF-κB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chem. to yield nano-molar signaling inhibitors. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Synthetic Route of C11H20N2O2S).
tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H20N2O2S