Synthesis and biological activities of 3-methoxy-6-substituted-5,6-dihydropyrrolo[3,4-b]pyridin-7-ones was written by Sun, Guanglong;Zhang, Weiwei;Zhan, Xiaoping;Liu, Zenglu;Mao, Zhenmin. And the article was included in Youji Huaxue in 2014.Safety of Methyl 3-methylpicolinate This article mentions the following:
A series of thalidomide derivatives named 3-methoxy-6-substituted 5,6-dihydropyrrolo[3,4-b]pyridin-7-ones 1a-1l, which have never been reported in literature, were synthesized from 3-methoxypyridine-2-carboxylic acid Me ester (I) and different amines by cyclization reaction. The intermediate I was produced via hydrolysis, esterification, nitration reaction, methoxy substitution, bromination reaction using 3-methyl-pyridine-2-carbonitrile as the starting material. The structures of all compounds have been confirmed by 1H NMR, 13C NMR and HRMS techniques. The target compounds were evaluated for their inhibitory activity against HCT-116, MG-63, MCF-7, HUVEC and HMVEC cells by MTT (thiazolyl blue tetrazolium bromide) method, and the results indicated that almost all of them had no obvious inhibitory effect on normal human cells, some compounds only displayed obvious inhibitory effect on MG-63 cells while other compounds presented excellent inhibitory activities against all the three kinds of tumor cells, among which compounds two compounds exhibited most potent activities. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Safety of Methyl 3-methylpicolinate).
Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of Methyl 3-methylpicolinate