Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Recommanded Product: 26218-75-726218-75-7, Name is Methyl 6-bromopicolinate, SMILES is COC(C1=CC=CC(=N1)Br)=O, belongs to pyridine-derivatives compound. In a article, author is Liu, Cheng-Yuan, introduce new discover of the category.
Nickel-mediated cross-coupling via C-O activation assisted by organoaluminum
We report the alkylation and arylation cross-coupling of aryl ethers based on C-O bond activation using a nickel catalyst and organoaluminum reagents. Ni(cod)(2) in combination with 1,2-bis(dicyclohexylphosphino)ethane ligand in toluene solution at 130 degrees C are the best conditions. The naphthyl ether or methoxy pyridine derivatives are suitable substrates for alkylation and arylation reaction with a wider scope of aluminum reagents in good yields. Computational analysis on the pyridine substrate is provided to help delineate the mechanistic pathway and demonstrate the important aspects of the cooperative interaction bimetallic catalysis. First, the coordination of AlMe3 to the O atom of pyridine is essential for C-O activation. Second, the beta-H transfer from methoxy to pyridine could be discouraged through the use of bidentate phosphine as a ligand. Finally, excess AlMe3 reagent is critical for facilitating a reductive elimination process.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 26218-75-7. Recommanded Product: 26218-75-7.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem