Structure of 6-methylpicolinic acid N-oxide and its derivatives was written by Szafran, M.. And the article was included in Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques in 1962.COA of Formula: C7H9NO This article mentions the following:
Infrared absorption spectra in Nujol or KBr for 4-substituted 6-methylpicolinic acid N-oxides (I) and their methylation products indicate the structure II for I (R = NO2), two contributing tautomeric structures (II and III) for I (R = H and OMe), and structure IV for I (R = NH2). The acids I were esterified with CH2N2 (V) in MeOH and Et2O. Me 4-nitro-6-methylpicolinate N-oxide, m. 128.5-29°, was prepared in 92% yield and gave the amide, m. 265-6° (decomposition), on treatment with NH4OH. The methylation product, m. 166° from IV was obtained in 90% yield and gave on hydrolysis 4-amino-6-methylpicolinic acid, m. 296° (decomposition). Hydrolysis of methylated (CH2N2) 4-methoxy-6-methylpicolinic acid N-oxide (oil) with NaOH and KOH afforded a mixture of 4-methoxy-2-picoline (70-75%) and 4-methoxypicolinic acid N-oxide (21-25%). 6-Methylpicolinic acid N-oxide reacted with V to give 6-methyl-2-carbomethoxypyridine N-oxide (40%) and an ionic compound which decomposed on distillation In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1COA of Formula: C7H9NO).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H9NO