Synthesis of zidovudine impurity 3′-chloro-3′-deoxythymidine was written by Wang, Rui;Zhong, Xiao-feng;Zou, Hui;Tian, Lei. And the article was included in Anhui Huagong in 2015.SDS of cas: 628-13-7 This article mentions the following:
3′-Chloro-3′-deoxythymidine was synthesized from thymidine through ring closing which then opened by chloro, finally deprotection. The impurity could be used as the reference substance of the related substances in the quality control of Zidovudine. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7SDS of cas: 628-13-7).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 628-13-7