Derivatives of 1,2,3,4-tetrahydro-6-aminocarbazole, a serotonin antimetabolite was written by Kotler-Brajtburg, Janina. And the article was included in Acta Poloniae Pharmaceutica in 1963.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:
To ascertain whether the pharmacol. properties of 1,2,3,4-tetrahydro-6-aminocarbazole (I) depend on the presence of the NH2 group, several substitution products were prepared In tests with isolated rat uterus, they showed no antiserotonin activity. I (1.86 g.) suspended in 20 ml. 70% MeOH was treated with 2 g. AcONa.3H2O and, with stirring, 2.28 g. p-MeC6H4SO2Cl, and the mixture stirred 30 min. at room temperature, 15 min. at 40-5°, and cooled to yield 2.7 g. N-[6-(1,2,3,4-tetrahydrocarbazolyl)]-p-toluenesulfonamide, m. 219-20° (80% Me2CO). A solution of 3.72 g. I in 40 ml. 40% AcOH was treated at 5-8° with alternate portions of 1.4 g. NaNO2 in 3 ml. H2O and 1 ml. HCl, the mixture stirred 30 min., treated with 2.2 g. 2,6-diaminopyridine (II) in 40 ml. 20% Ac0H, stirred 1 hr. at 10-12°, and filtered, and the filtrate alkalized with NH4OH to give 2.5 g. III, m. 196-8°, purified via the hydrochloride. When 3.06 g. III in 100 ml. AcOH was stirred 1 hr. at room temperature with 10 ml. AcCl, 72% mono-Ac derivative of III was obtained, m. 196-8°. Similarly acetylated, II gave 93% 2-amino-6-acetylaminopyridine-HCl, m. 245° (decomposition) (MeOH); the free base (IV) m. 156-7° (H2O). Coupling IV with a diazo derivative of I gave an orange dye whose purification was unsuccessful. I-HCl did not melt up to 350°. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide