Identifying specific conformations by using a carbohydrate scaffold: Discovery of subtype-selective LPA-receptor agonists and an antagonist was written by Tamaruya, Yoko;Suzuki, Masato;Kamura, Goshu;Kanai, Motomu;Hama, Kotaro;Shimizu, Kumiko;Aoki, Junken;Arai, Hiroyuki;Shibasaki, Masakatsu. And the article was included in Angewandte Chemie, International Edition in 2004.Computed Properties of C10H17NO2 This article mentions the following:
Stable and potent subtype-selective lysophosphatidic acid (LPA) analogs (agonists and an antagonist) were developed by using carbohydrates as a core structure. An array of mols. with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C10H17NO2