Practical routes toward the synthesis of 2-halo- and 2-(alkylamino)-4-pyridinecarboxaldehydes was written by Frey, L. F.;Marcantonio, K.;Frantz, D. E.;Murry, J. A.;Tillyer, R. D.;Grabowski, E. J. J.;Reider, P. J.. And the article was included in Tetrahedron Letters in 2001.Electric Literature of C6H3FN2 This article mentions the following:
We recently required an efficient synthesis of 2-halo- and 2-(alkylamino)-4-pyridinecarboxaldehydes. Several routes to these compounds were investigated resulting in efficient and practical procedures from readily available and inexpensive starting materials. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Electric Literature of C6H3FN2).
2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C6H3FN2