Discovery of (E)-3-((Styrylsulfonyl)methyl)pyridine and (E)-2-((Styrylsulfonyl)methyl)pyridine Derivatives as Anticancer Agents: Synthesis, Structure-Activity Relationships, and Biological Activities was written by Lu, Tiangong;Goh, Aik Wye;Yu, Mingfeng;Adams, Julian;Lam, Frankie;Teo, Theodosia;Li, Peng;Noll, Ben;Zhong, Longjin;Diab, Sarah;Chahrour, Osama;Hu, Anran;Abbas, Abdullahi Y.;Liu, Xiangrui;Huang, Shiliang;Sumby, Christopher J.;Milne, Robert;Midgley, Carol;Wang, Shudong. And the article was included in Journal of Medicinal Chemistry in 2014.Related Products of 15128-90-2 This article mentions the following:
ON01910.Na is a highly effective anticancer agent that induces mitotic arrest and apoptosis. Clin. studies with ON01910 in cancer patients have shown efficacy along with an impressive safety profile. While ON01910 is highly active against cancer cells, it has a low oral availability and requires continuous i.v. infusion or multiple gram doses to ensure sufficient drug exposure for biol. activity in patients. We have identified two novel series of styrylsulfonyl-methylpyridines. Lead compounds 8, 9a, 18 and 19a are highly potent mitotic inhibitors and selectively cytotoxic to cancer cells. Impressively, these compounds possess excellent pharmaceutical properties and two lead drug candidates 9a and 18 demonstrated antitumor activities in animal models. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Related Products of 15128-90-2).
3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 15128-90-2