Designing of novel zinc(II) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities was written by Dasgupta, Sanchari;Karim, Suhana;Banerjee, Saswati;Saha, Moumita;Das Saha, Krishna;Das, Debasis. And the article was included in Dalton Transactions in 2020.Name: Phenyl(pyridin-2-yl)methanone This article mentions the following:
Three asym. tridentate acyl hydrazone Schiff base ligands L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone, resp. Three bio-relevant mononuclear Zn(II) complexes [Zn(L1)Cl2]·2H2O (1), [Zn(L2)Cl2] (2) and [Zn(L3)Cl2] (3) were synthesized by treatment of Zn(II) chloride with the corresponding Schiff base ligands and characterized by the usual physicochem. techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal x-ray anal. All complexes were able to hydrolyze the P-O bond of the phosphate monoester in 90% (volume/volume) DMSO-H2O medium using 4-nitrophenylphosphate (4-NPP) as model substrate and the trend in their activity is 1 ≈ 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1–3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human nonsmall lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Name: Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: Phenyl(pyridin-2-yl)methanone