Rhodium-Catalyzed CxS and CxN Functionalization of Arenes: Combination of CxH Activation and Hypervalent Iodine Chemistry was written by Wang, Fen;Yu, Xinzhang;Qi, Zisong;Li, Xingwei. And the article was included in Chemistry – A European Journal in 2016.Synthetic Route of C12H11N This article mentions the following:
Rhodium-catalyzed sulfonylation, thioetherification, thiocyanation, and other heterofunctionalizations of arenes bearing a heterocyclic directing group were realized. The reaction proceeds by initial RhIII-catalyzed CxH hyperiodination of arene at room temperature followed by uncatalyzed nucleophilic functionalization. A diaryliodonium salt was isolated as an intermediate, which represents umpolung of the arene substrate, in contrast to previous studies that suggested umpolung of the coupling partner. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C12H11N