Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents was written by Tung, Yen-Shih;Coumar, Mohane Selvaraj;Wu, Yu-Shan;Shiao, Hui-Yi;Chang, Jang-Yang;Liou, Jing-Ping;Shukla, Paritosh;Chang, Chun-Wei;Chang, Chi-Yen;Kuo, Ching-Chuan;Yeh, Teng-Kuang;Lin, Chin-Yu;Wu, Jian-Sung;Wu, Su-Ying;Liao, Chun-Chen;Hsieh, Hsing-Pang. And the article was included in Journal of Medicinal Chemistry in 2011.Related Products of 24103-75-1 This article mentions the following:
Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug candidate for BPR0L075 I, an indole-based anticancer agent. For this purpose, 5,6-fused bicyclic heteroaromatic scaffolds were designed and synthesized through shuffling of the nitrogen from the N-1 position or by insertion of one or two nitrogen atoms into the indole core of I. Among these, 7-azaindole core II showed potent in vitro anticancer activity and improved oral bioavailability (F = 35%) compared with I (F < 10%). In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Related Products of 24103-75-1).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 24103-75-1