Iridium-Catalyzed Unreactive C(sp3)-H Amination with 2,2,2-Trichloroethoxycarbonyl Azide was written by Zhang, Tao;Hu, Xuejiao;Dong, Xunqing;Li, Guigen;Lu, Hongjian. And the article was included in Organic Letters in 2018.COA of Formula: C8H11N This article mentions the following:
An additive-assisted iridium-catalyzed directed C(sp3)-H amination with 2,2,2-trichloroethoxycarbonyl azide as an amino source is reported. Both carboxylate anions and the corresponding cations in the additives are crucial to achieve satisfactory efficiency. Sodium acetate or n-pentanoic acid can promote the amination of various primary C(sp3)-H bonds adjacent to secondary, tertiary, and quaternary carbons in ketoximes or N-aromatic heterocycles, resp., providing a practical route to versatile β-amino ketoxime and N-heteroaryl ethanamine derivatives The amination products can be treated as isocyanate analogs and can be converted to other useful amino functionalities. An iridacyclic compound was isolated and identified as a plausible intermediate. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4COA of Formula: C8H11N).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C8H11N