3D-QSAR, Synthesis, and antimicrobial activity of 1-Alkylpyridinium Compounds as Potential Agents to Improve Food Safety was written by Rodriguez-Morales, Sergio;Compadre, R. Lilia;Castillo, Rafael;Breen, Philip J.;Compadre, Cesar M.. And the article was included in European Journal of Medicinal Chemistry in 2005.Category: pyridine-derivatives This article mentions the following:
Cetylpyridinium chloride (CPC), an alkylpyridinium compound has been recently approved by the US Food and Drug Administration to reduce bacterial contamination in poultry. Although CPC is very effective and has a very good safety record, its relatively high lipophilicity may limit its use in high fat containing foods such as beef. In this study, the CoMFA anal. (3D-QSAR) of the antimicrobial activity of 60 N-alkylpyridinium compounds against different bacteria was presented. CoMFA contours showed that the activity is highly influenced by the steric factor. Based in these contours, new candidates were designed, which were synthesized and characterized by spectroscopic data. MIC activity over Gram pos. and Gram neg. microorganisms validated the 3D-QSAR study. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Category: pyridine-derivatives).
1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives