Cobalt-Catalyzed C-H Allylation of Arenes with Allylic Amines was written by Yan, Rui;Yu, Hang;Wang, Zhong-Xia. And the article was included in Chinese Journal of Chemistry in 2021.Synthetic Route of C12H11N This article mentions the following:
A [Cp*Co(CO)I2] effectively catalyzes pyridyl-directed C-H allylation of arenes with allylic amines (such as., N-allyl-N-methylaniline, N,N-diallylaniline, N-allylaniline, etc.) in the presence of AgOAc and CF3COOAg. The reaction features ortho-position monoallylation of 2-pyridylarenes giving the allylated arenes in moderate to high yields. A range of functional groups including OMe, Me, Ph, F, Cl, Br, CF3, C(O)Me, COOEt, and COOH groups are tolerated. Pyrimidyl-directed C-H allylation of arenes was also performed under the same conditions. Reaction of 2-phenylpyrimidine, 2-(4-methoxyphenyl)pyrimidine, and 2-(3-fluorophenyl)pyrimidine leads to a mixture of ortho-position mono- and bisallylation products I (R = H, 4-OMe, 3-F). Reaction of other 2-(substituted aryl)pyrimidines resulted in ortho-position monoallylation products. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C12H11N