Water Soluble Coumarin Quaternary Ammonium Chlorides: Synthesis and Biological Evaluation was written by Karatas, Mert O.;Noma, Samir A. A.;Guerses, Canbolat;Balcioglu, Sevgi;Ates, Burhan;Alici, Buelent;Cakir, Uemit. And the article was included in Chemistry & Biodiversity in 2020.Computed Properties of C5H6ClN This article mentions the following:
In the present study, coumarin-bearing three pyridinium and three tetra-alkyl ammonium salts were synthesized. The compounds were fully characterized by 1H- and 13C-NMR, LC/MS and IR spectroscopic methods and elemental analyses. The cytotoxic properties of all compounds were tested against human liver cancer (HepG2), human colorectal cancer (Caco-2) and non-cancer mouse fibroblast (L-929) cell lines. Some compounds performed comparable cytotoxicity with standard drug cisplatin. Antibacterial properties of the compounds were tested against Gram-neg. Escherichia coli and Gram-pos. Bacillus subtilis bacteria, but the compounds did not have any antibacterial effect against both bacteria. Enzyme inhibitory properties of all compounds were tested on the activities of human carbonic anhydrase I and II, and xanthine oxidase. All compounds inhibited both enzymes more effectively than standard drugs, acetazolamide and allopurinol, resp. The biol. evaluation results showed that ionic and water soluble coumarin derivatives are promising structures for further investigations especially on enzyme inhibition field. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Computed Properties of C5H6ClN).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Computed Properties of C5H6ClN