Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability was written by Patel, Leena;Chandrasekhar, Jayaraman;Evarts, Jerry;Forseth, Kristen;Haran, Aaron C.;Ip, Carmen;Kashishian, Adam;Kim, Musong;Koditek, David;Koppenol, Sandy;Lad, Latesh;Lepist, Eve-Irene;McGrath, Mary E.;Perreault, Stephane;Puri, Kamal D.;Villasenor, Armando G.;Somoza, John R.;Steiner, Bart H.;Therrien, Joseph;Treiberg, Jennifer;Phillips, Gary. And the article was included in Journal of Medicinal Chemistry in 2016.Formula: C8H10N2 This article mentions the following:
Aberrant signaling of phosphoinositide-3-kinase delta (PI3K-delta) has been implicated in numerous pathologies including hematol. malignancies and rheumatoid arthritis. Described in this manuscript is the discovery, optimization and in vivo evaluation of a novel series of pyridine-containing PI3K-delta inhibitors. This work led to the discovery of I, a highly selective inhibitor of PI3K-delta which displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis. In the experiment, the researchers used many compounds, for example, 5-Cyclopropylpyridin-3-amine (cas: 1314353-68-8Formula: C8H10N2).
5-Cyclopropylpyridin-3-amine (cas: 1314353-68-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C8H10N2