Synthesis and structure-activity relationships of N 3-pyridylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists was written by Hartz, Richard A.;Ahuja, Vijay T.;Schmitz, William D.;Molski, Thaddeus F.;Mattson, Gail K.;Lodge, Nicholas J.;Bronson, Joanne J.;Macor, John E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Safety of 3-Amino-2,6-dimethoxypyridine This article mentions the following:
A series of N 3-pyridylpyrazinones was investigated as corticotropin-releasing factor-1 receptor antagonists. It was observed that the binding affinity of analogs containing a pyridyl group was influenced not only by the substitution pattern on the pyridyl group, but also by the pK a of the pyridyl nitrogen. Analogs containing a novel 6-(difluoromethoxy)-2,5-dimethylpyridin-3-amine group e. g., I were among the most potent N3-pyridylpyrazinones synthesized. The synthesis and SAR of N 3-pyridylpyrazinones is described herein. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Safety of 3-Amino-2,6-dimethoxypyridine).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 3-Amino-2,6-dimethoxypyridine