A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts was written by Kong, Xianqiang;Chen, Yiyi;Chen, Xiaohui;Lu, Zheng-Xuan;Wang, Wei;Ni, Shao-Fei;Cao, Zhong-Yan. And the article was included in Organic Letters in 2022.Electric Literature of C12H9NO This article mentions the following:
By merging electrocatalysis and nickel catalysis, a unified strategy was successfully applied for preparing aryl ketones ArC(O)Ph [Ar = Ph, 4-ClC6H4, 4-MeC6H4, etc.], amides ArC(O)NR1R2 [Ar = Ph, 4-ClC6H4, 4-MeC6H4, etc.; R1 = R2 = Me, Et; R1R2 = CH2(CH2)2CH2, CH2CH2OCH2CH2], esters ArC(O)OR [Ar = Ph, 2-MeC6H4, 4-FC6H4, etc.; R = Me, Et] or aldehydes ArCHO [Ar = Ph, 4-MeC6H4, 4-PhC6H4, etc.] via decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C12H9NO