Chemical microarrays to identify ligands that bind pathogenic cells was written by Barrett, Olivia J.;Childs, Jessica L.;Disney, Matthew D.. And the article was included in ChemBioChem in 2006.Application of 28020-37-3 This article mentions the following:
The use of microarrays to identify new ligands for cells by interrogating their binding to a library of organic ligands is described. The advantages of using microarrays include assay miniaturization and the manner in which ligands are displayed in a small area. This display mimics interactions that occur at cell-cell interfaces and amplifies binding affinities. In addition, a series of array surfaces was tested for resisting nonspecific binding, which includes amine-, BSA, and agarose- (aldehyde-) coated glass, plain glass, and glass coated with ethanolamine prepared in a two-step procedures from amine-coated slides using the pathogenic Pseudomonas aeruginosa, which forms sticky biofilms. The agarose slides offer an alternative as a more general arraying substrate to study the binding of microarray-immobilized ligands to cells. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Application of 28020-37-3).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 28020-37-3