Rapid and Efficient Construction of Indolizino[3,4,5-ab]isoindole Skeletons by a Rhodium-Catalyzed Tandem Reaction was written by Liu, Chang;Wu, Shaonan;Sun, Wan;Meng, Haifang;Xing, Siyang;Zhu, Bolin. And the article was included in Asian Journal of Organic Chemistry in 2020.Formula: C12H11N This article mentions the following:
A facile rhodium-catalyzed tandem reaction of two mols. of acrylates with two mols. of 2-phenylpyridines involving sequential C-H activation, Michael addition, [12+2] cycloaddition and oxidative aromatization was described. A series of indolizino[3,4,5-ab]isoindole compounds were efficiently afforded in good yields by the formation of two C-C bonds, two C=C bonds and one C-N bond. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C12H11N