Synthesis of melatonin analogues derived from furo[2,3-b]- and -[2,3-c]pyridines by use of a palladium-copper catalyst system was written by Van de Poel, Herve;Guillaumet, Gerald;Viaud-Massuard, Marie-Claude. And the article was included in Heterocycles in 2002.SDS of cas: 51834-97-0 This article mentions the following:
2,3,5-Substituted furo[2,3-b]pyridine was synthesized by palladium-catalyzed reaction of 5-bromo-2-hydroxy-3-iodopyridine and phenylacetylene with (Ph3P)2PdCl2, CuI in Et3N. A carbonylative cyclization of 5-hydroxy-2-methoxy-4-(2-phenylethynyl)pyridine with carbon monoxide in methanol with PdCl2, CuCl2 under basic conditions, has been accomplished to prepare Me 2,5-substituted furo[2,3-c]pyridine-3-carboxylate. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0SDS of cas: 51834-97-0).
5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 51834-97-0