Synthesis of 3-hydroxy- and 3-carboxy-Δ2-isoxazoline amino acids and evaluation of their interaction with GABA receptors and transporters was written by Conti, Paola;De Amici, Marco;Pinto, Andrea;Tamborini, Lucia;Grazioso, Giovanni;Frolund, Bente;Nielsen, Birgitte;Thomsen, Christian;Ebert, Bjarke;De Micheli, Carlo. And the article was included in European Journal of Organic Chemistry in 2006.Computed Properties of C10H17NO2 This article mentions the following:
A series of 3-hydroxy- and 3-carboxy-Δ2-isoxazoline amino acids acids, structurally related to the GABAA agonist THIP and to the GABA uptake inhibitors THPO, was prepared by means of synthetic strategies involving the 1,3-dipolar cycloaddition of nitrile oxides. All derivatives were submitted to a pharmacol. investigation at both GABA receptors and transporters. Unfortunately, all amino acids were devoid of activity except for a very low affinity at GABAA receptors, displayed by compounds I and II. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C10H17NO2