Design, Synthesis and In Vitro Cytotoxic Activity of Certain 2-[3-Phenyl-4-(pyrimidin-4-yl)-1H-pyrazol1-yl]acetamide Derivatives was written by Al-Sanea, M. M.;Parambi, D. G. T.;Shaker, M. E.;Elsherif, H. A. M.;Elshemy, H. A. H.;Bakr, R. B.;Al-Warhi, T. I. M.;Gamal, M.;Abdelgawad, M. A.. And the article was included in Russian Journal of Organic Chemistry in 2020.Application In Synthesis of Pyridin-4-ol This article mentions the following:
A series of 2-[4-(2-oxypyrimidin-4-yl)-3-(3-methoxy-5-methylphenyl)-1H-pyrazol-1-yl]acetamide derivatives I [Ar = pyridin-3-yl, 2-H2NC6H4, 4-MeOC6H4, etc.] was synthesized and their in vitro antiproliferative activity was assessed against 60 NCI cell lines at a single dose concentration of 10μM. Compound I [Ar = 3,4-(MeO)2C6H3] showed an appreciable cancer cell growth inhibition (about 20%) against eight cancer cell lines (HOP-92, NCI-H226, 79SNB-75, A498, SN12C, UO-31, T-47D and MDA-MB-468). In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application In Synthesis of Pyridin-4-ol).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application In Synthesis of Pyridin-4-ol