Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 628-13-7
Biocompatible and low-cost pyridinium halides catalysts promoted ring-opening polymerizations of cyclic esters in bulk was written by Wang, Haixin;Yao, Zhiwei;Li, Zhenjiang;Zhu, Yuejia;Zhang, Chan;Luo, Zikun;Guo, Tianfo;Gao, Yu;Zhang, Lei;Guo, Kai. And the article was included in European Polymer Journal in 2020.HPLC of Formula: 628-13-7 This article mentions the following:
Polyesters produced by ring-opening polymerization (ROP) of cyclic monomers using organocatalysts were well developed in academia. Industrially viable ROPs were polymerizations at elevated temperatures in the bulk, thus desirable features of useful organocatalysts would be thermal stable, reasonably active in fast polymerization but mild enough to avoid transesterification. More importantly, the polyesters containing residue organocatalyst should met biosafety regulations. In these regards, series of pyridinium halides readily prepared by one step from mass-produced pyridines and hydrohalic acids were evaluated in ROPs of L-lactide (LLA), trimethylene carbonate (TMC), δ-valerolactone, and ε-caprolactone in the bulk. An optimal catalyst 4-(N,N-dimethylamino)pyridine hydrochloride (DMAP·HCl) was examined in the catalytic performances in ROPs of LLA, TMC, and diblock copolymerization affording PTMC-b-PLLA. Bulk ROP of LLA at 140 °C produced PLLAs by near quant. conversions with precise mol. weights (Mn,NMR = 3.3-16.6 kg mol-1) and narrow dispersities (D = 1.13-1.17). Kinetics data, chain extension experiments, and MALDI-ToF MS anal. all supported the controlled/living nature of the ROPs. A bifunctional activation mechanism in which pyridinium activated the monomer and halide activated the initiator/chain end was proposed and validated by 1H NMR and 13C NMR titrations Poly(L-lactide) samples prepared by bulk ROPs of LLA that containing residue catalyst DMAP·HCl were tested by MTT assay in L929 mouse fibroblasts in vitro. High level of relative growth rate (RGR 93.6-96.8%) revealed favorable biosafety of the sample PLLAs. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7HPLC of Formula: 628-13-7).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 628-13-7
Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem