Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6,8(7H)-diones was written by Jeschke, Peter;Harder, Achim;Etzel, Winfried;Gau, Wolfgang;Goehrt, Axel;Benet-Buchholz, Jordi;Thielking, Gerhard. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Name: 3,5-Dimethylpyridine 1-oxide This article mentions the following:
The racemic 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6,8(7H)-diones I [R = Me, Et, cyclopropyl, Bu, CH2Ph, (S)CHMePh] represent novel tricyclic compounds with strong in vivo efficacy against the parasitic nematode Haemonchus contortus Rudolphi in sheep. The synthesis of endo-I and the resolution of I [R = Et] by HPLC are reported. The absolute configuration of the most anthelmintically active (4aS,5aS,8aS,8bR)-enantiomer was determined by single crystal X-ray anal. using its stable CuCl2 (2:1)-complex. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Name: 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 3,5-Dimethylpyridine 1-oxide