Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation was written by Kroth, Heiko;Sreenivasachary, Nampally;Hamel, Anne;Benderitter, Pascal;Varisco, Yvan;Giriens, Valerie;Paganetti, Paolo;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2016.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate This article mentions the following:
It is assumed that amyloid-β aggregation is a crucial event in the pathogenesis of Alzheimer’s disease. Novel 2,6-disubstituted pyridine derivatives were designed to interact with the β-sheet conformation of Aβ via donor-acceptor-donor hydrogen bond formation. A series of pyridine derivatives, e.g., I•3HCl, were synthesized and tested regarding their potential to inhibit the aggregation of Aβ. The 2,6-diaminopyridine moiety was identified as a key component to inhibit Aβ aggregation. Overall, compounds having three 2,6-disubstituted pyridine units separated by at least one C2- or C3-linker displayed the most potent inhibition of Aβ aggregation. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate).
tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: tert-Butyl methyl(6-methylpyridin-2-yl)carbamate